May_Precision Healthcare|Precision Healthcare Industry Key Pulse, Focus on 4 Major Trends

Published On: 2023/05/15|Categories: 大健康(Healthcare)|

In view of the global trend of an aging society, the significant increase in health care expenses has become a major economic and social challenge for many countries around the world, the current medical behavior is to see a doctor for treatment only after the onset of a disease, if the concept is changed in the subhealthy to the onset of the disease, or to manage the health status of the health status of the time so that health is effectively maintained, it will reshape the medical behavior from health care to the health management of the new chapter is expected to reduce the heavy burden of health care and reduce the cost of social care, and will lead to a new wave of industry prospects. It is expected to reduce the heavy burden of medical care and the cost of social care, as well as bring about a new wave of industrial profitability.

Precision medicine covers the areas of precision prevention, precision prediction, precision diagnosis and precision treatment from the medical side, while precision health focuses on precision prevention and precision prediction from the consumer health side, both of which are essential and closely related to the needs of human life. 2015 saw the introduction of Precision Medicine Initiatives (PMI) in the United States, following the Human Genome Project, to study the relationship between personal genes and healthcare benefits. With the approval of the first Luxturna gene therapy in 2017, in addition to establishing the medical application of gene therapy, it also symbolizes the opening of the era of personalized (genetic) medicine, which emphasizes the importance of health in the human life process, and the need for precise health at all ages is the only way to achieve human health and the future of medical development. The future of human health and medical development is to have accurate health for all ages, and then the All of Us Precision Health was born (U.S. All of Us Research Program), and the genetic analysis of millions of people and the health data tracking database were carried out. In this context, with the core of biomedical data such as genetic, physiological, psychological, and behavioral data, biomarkers, clinical application standards, or health monitoring indicators of value for medical applications (detection, screening, diagnosis, or treatment) can be identified through translational medicine, combined with ICT, big data, AI/ML, and 5G, and combined with other drugs/medicines/therapeutics, either individually or through software or digital devices, and then used as the basis for the development of a new drug/medicine/therapeutic. Precision medicine and precision health industry ecosystem is regarded as the international healthcare development epiphany, and is also the focus of international hot money investment in recent years.

以技術和應用發展角度來看,Forbes和MIT等多家機構觀測精準醫療健康科技的脈動,發現正在崛起的醫療健康科技趨勢分別為

(1) AI /ML數據整合精準醫學,AI /ML醫療相關技術深植醫療健康生態系統。目前AI /ML在醫療設備應用的發展迅速,除嵌入醫療設備累積數量持續攀高(UFDA2022/10已核准521件)外,國際醫材大廠已著手佈局收購整合AI /ML輔助診斷平台;

(2)遠距醫療提供更有效和成本效益的照護,如OMRON遠程心臟監測服務可監控患者身體狀況和藥物依從性,MedWand Solutions遠程醫療體檢服務,或VirtualCare遠距精準偵測病患臨床身體生理數據等;

(3)零售醫療崛起,零售醫療保健業務量倍增,如亞馬遜推出Amazon Clinic虛擬診療平台和Prime會員藥品訂閱外送服務,將平台串接用戶與第三方醫療服務商,提供虛擬診治和超過20種疾病用藥;

(4)醫用穿戴式裝置結合更多功能支持邊緣運算分析,如數位穿戴式裝置導入AI /ML更全面化,2023 CES大展呈現更多新世代醫療器材和創新數位健康裝置AI /ML標配化;

以上不難發現,AI /ML大數據和智慧醫療工具已廣泛應用在精準醫療和精準健康的產品和場域,現階段專屬個人化的醫療服務也逐步蓬勃發展,其中如何搶先一步在疾病惡化前或變壞前的提早發現「微病兆」呢? 或在尚未生病前及早預防的技術,如精準醫療早期診斷和精準健康預防管理更被視為重點的發展領域,此外如何研發與疾病發生高度關聯性的精準新技術,降低成本,讓應用普及化,也成為精準醫療和精準健康需要克服的關鍵問題。

液態活檢(liquid biopsy)是精準醫療早期診斷的熱門領域,更快、更便宜、更準的多項癌症早篩已成重要發展趨勢,以抽血就能檢測出微量癌細胞種類、預測復發情形,或作為術後化療/或預防性治療的指導,可克服癌症早期無症狀難發現、實體腫瘤切片難取得、治療時效拖延和復發監控等限制,此外隨著新實證醫學(evidence-based ) 、臨床真實數據(Real World Data, RWD)和真實世界證據(Real World Evidence, RWE)的突破,除升級現行醫學治療指南(medical guideline)外,過去臨床醫師很難相信戴智慧手錶能有效管理心律不整的風險,隨著2019年新英格蘭期刊發表智慧手錶大規模評估心房顫動和apple watch許多救人事蹟分享,也讓精準健康穿戴和非穿戴裝置備落地應用受市場關注。

精準醫療健康產業台廠優勢

Apple執行長Tim Cook曾表示「健康」將是Apple “對人類最大的貢獻”,表示精準健康和醫療科技仍是科技業跨域相當看好的產業領域之一,精準醫療健康產業是以「健康大數據」為核心,圍繞著基因、生活型態、疾病和營養四者相互作用而影響健康,將個人基因表現、個人健康型態和臨床資訊,用大數據和AI /ML分析,量身打造對病人最適合的醫療和健康管理方式。

盤點台灣在精準醫療健康產業發展優勢包含三方面分別為

(1)建置價值型醫療健康數據庫,如台灣健保資料庫、TPMI精準醫學資料庫、台灣人體生物資料庫(Taiwan BioBank)和醫療影像資料;

(2)台灣科技業掌握ICT關鍵技術,如軟硬體整合技術如鴻海、緯創、佳世達和宏碁; AI運算如廣達、力晶和聯發科; 感測器Sensor、8K影像技術如群創、友達和瑞昱,以及5G通訊技術平台,如遠傳、中華電和亞太等

(3)關鍵領域人才如大數據領域專家、多體學體學資料(omics data)領域專家和AI分析領域專家等,以台灣ICT產業為後盾整合一流醫學專家的跨域合作,陸續已有多項產品通過US FDA核准上市,雖然目前國際間許多精準醫療健康產品仍是叫好不叫座,且多項新創商業模式如綁定處方或外益保單仍在喘息中摸索,但觀察美國FDA醫材發展前哨站突破性醫材認定清單,不難發現精準醫療健康科技仍是發展主流,隨著精準醫療健康剛需應用更加明確,相信其產業前景指日可待。

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